The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.
Identifieur interne : 001626 ( Main/Exploration ); précédent : 001625; suivant : 001627The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.
Auteurs : Rebecca B. Delconte [Australie] ; Wei Shi [Australie] ; Priyanka Sathe [Australie] ; Takashi Ushiki [Australie] ; Cyril Seillet [Australie] ; Martina Minnich [Autriche] ; Tatiana B. Kolesnik [Australie] ; Lucille C. Rankin [Australie] ; Lisa A. Mielke [Australie] ; Jian-Guo Zhang [Australie] ; Meinrad Busslinger [Autriche] ; Mark J. Smyth [Australie] ; Dana S. Hutchinson [Australie] ; Stephen L. Nutt [Australie] ; Sandra E. Nicholson [Australie] ; Warren S. Alexander [Australie] ; Lynn M. Corcoran [Australie] ; Eric Vivier [France] ; Gabrielle T. Belz [Australie] ; Sebastian Carotta [Australie] ; Nicholas D. Huntington [Australie]Source :
- Immunity [ 1097-4180 ] ; 2016.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Cellules tueuses naturelles (cytologie), Cellules tueuses naturelles (immunologie), Cytométrie en flux, Différenciation cellulaire (immunologie), Facteurs de transcription (immunologie), Facteurs de transcription (métabolisme), Femelle, Interleukine-15 (immunologie), Lignage cellulaire (immunologie), Mâle, Protéine d'inhibition de la différenciation-2 (immunologie), RT-PCR, Récepteurs à l'interleukine-15 (immunologie), Récepteurs à l'interleukine-15 (métabolisme), Souches mutantes de souris, Souris.
- MESH :
- cytologie : Cellules tueuses naturelles.
- immunologie : Cellules tueuses naturelles, Différenciation cellulaire, Facteurs de transcription, Interleukine-15, Lignage cellulaire, Protéine d'inhibition de la différenciation-2, Récepteurs à l'interleukine-15.
- métabolisme : Facteurs de transcription, Récepteurs à l'interleukine-15.
- Animaux, Cellules cultivées, Cytométrie en flux, Femelle, Mâle, RT-PCR, Souches mutantes de souris, Souris.
English descriptors
- KwdEn :
- Animals, Cell Differentiation (immunology), Cell Lineage (immunology), Cells, Cultured, Female, Flow Cytometry, Inhibitor of Differentiation Protein 2 (immunology), Interleukin-15 (immunology), Killer Cells, Natural (cytology), Killer Cells, Natural (immunology), Male, Mice, Mice, Mutant Strains, Receptors, Interleukin-15 (immunology), Receptors, Interleukin-15 (metabolism), Reverse Transcriptase Polymerase Chain Reaction, Transcription Factors (immunology), Transcription Factors (metabolism).
- MESH :
- chemical , immunology : Inhibitor of Differentiation Protein 2, Interleukin-15, Receptors, Interleukin-15, Transcription Factors.
- cytology : Killer Cells, Natural.
- immunology : Cell Differentiation, Cell Lineage, Killer Cells, Natural.
- chemical , metabolism : Receptors, Interleukin-15, Transcription Factors.
- Animals, Cells, Cultured, Female, Flow Cytometry, Male, Mice, Mice, Mutant Strains, Reverse Transcriptase Polymerase Chain Reaction.
Abstract
The inhibitor of DNA binding 2 (Id2) is essential for natural killer (NK) cell development with its canonical role being to antagonize E-protein function and alternate lineage fate. Here we have identified a key role for Id2 in regulating interleukin-15 (IL-15) receptor signaling and homeostasis of NK cells by repressing multiple E-protein target genes including Socs3. Id2 deletion in mature NK cells was incompatible with their homeostasis due to impaired IL-15 receptor signaling and metabolic function and this could be rescued by strong IL-15 receptor stimulation or genetic ablation of Socs3. During NK cell maturation, we observed an inverse correlation between E-protein target genes and Id2. These results shift the current paradigm on the role of ID2, indicating that it is required not only to antagonize E-proteins during NK cell commitment, but constantly required to titrate E-protein activity to regulate NK cell fitness and responsiveness to IL-15.
DOI: 10.1016/j.immuni.2015.12.007
PubMed: 26795246
Affiliations:
- Australie, Autriche, France
- Provence-Alpes-Côte d'Azur, Victoria (État), Vienne (Autriche)
- Marseille, Melbourne, Vienne (Autriche)
- Université de Melbourne
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Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en">The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.</title>
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<author><name sortKey="Minnich, Martina" sort="Minnich, Martina" uniqKey="Minnich M" first="Martina" last="Minnich">Martina Minnich</name>
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<orgName type="university">Université de Melbourne</orgName>
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<placeName><settlement type="city">Melbourne</settlement>
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<author><name sortKey="Rankin, Lucille C" sort="Rankin, Lucille C" uniqKey="Rankin L" first="Lucille C" last="Rankin">Lucille C. Rankin</name>
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<orgName type="university">Université de Melbourne</orgName>
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<author><name sortKey="Mielke, Lisa A" sort="Mielke, Lisa A" uniqKey="Mielke L" first="Lisa A" last="Mielke">Lisa A. Mielke</name>
<affiliation wicri:level="4"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010 Australia.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zhang, Jian Guo" sort="Zhang, Jian Guo" uniqKey="Zhang J" first="Jian-Guo" last="Zhang">Jian-Guo Zhang</name>
<affiliation wicri:level="4"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010 Australia.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Busslinger, Meinrad" sort="Busslinger, Meinrad" uniqKey="Busslinger M" first="Meinrad" last="Busslinger">Meinrad Busslinger</name>
<affiliation wicri:level="3"><nlm:affiliation>Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna, Austria.</nlm:affiliation>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Research Institute of Molecular Pathology, Dr. Bohr-Gasse 7, 1030 Vienna</wicri:regionArea>
<placeName><region type="land" nuts="2">Vienne (Autriche)</region>
<settlement type="city">Vienne (Autriche)</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name>
<affiliation wicri:level="1"><nlm:affiliation>QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>QIMR Berghofer Medical Research Institute, Herston, QLD 4006, Australia; School of Medicine, University of Queensland, Herston, QLD 4006</wicri:regionArea>
<wicri:noRegion>QLD 4006</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S" last="Hutchinson">Dana S. Hutchinson</name>
<affiliation wicri:level="1"><nlm:affiliation>Drug Discovery Biology, Monash Institute of Pharmacological Science, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Drug Discovery Biology, Monash Institute of Pharmacological Science, Parkville, VIC 3052</wicri:regionArea>
<wicri:noRegion>VIC 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nutt, Stephen L" sort="Nutt, Stephen L" uniqKey="Nutt S" first="Stephen L" last="Nutt">Stephen L. Nutt</name>
<affiliation wicri:level="4"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010 Australia.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nicholson, Sandra E" sort="Nicholson, Sandra E" uniqKey="Nicholson S" first="Sandra E" last="Nicholson">Sandra E. Nicholson</name>
<affiliation wicri:level="4"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010 Australia.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Alexander, Warren S" sort="Alexander, Warren S" uniqKey="Alexander W" first="Warren S" last="Alexander">Warren S. Alexander</name>
<affiliation wicri:level="4"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010 Australia.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Corcoran, Lynn M" sort="Corcoran, Lynn M" uniqKey="Corcoran L" first="Lynn M" last="Corcoran">Lynn M. Corcoran</name>
<affiliation wicri:level="4"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, VIC 3010 Australia.</nlm:affiliation>
<orgName type="university">Université de Melbourne</orgName>
<country>Australie</country>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name>
<affiliation wicri:level="1"><nlm:affiliation>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France; Immunologie, Hôpital de la Comception, Assistance Publique des Hôpitaux de Marseille, 13385 Marseille, France.</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>Centre d'Immunologie de Marseille-Luminy, Aix Marseille Université UM2, Inserm, U1104, CNRS UMR7280, 13288 Marseille, France; Immunologie, Hôpital de la Comception, Assistance Publique des Hôpitaux de Marseille, 13385 Marseille</wicri:regionArea>
<wicri:noRegion>13385 Marseille</wicri:noRegion>
<placeName><settlement type="city">Marseille</settlement>
<region type="région" nuts="2">Provence-Alpes-Côte d'Azur</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name>
<affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia. Electronic address: belz@wehi.edu.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052</wicri:regionArea>
<wicri:noRegion>VIC 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Carotta, Sebastian" sort="Carotta, Sebastian" uniqKey="Carotta S" first="Sebastian" last="Carotta">Sebastian Carotta</name>
<affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052</wicri:regionArea>
<wicri:noRegion>VIC 3052</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name>
<affiliation wicri:level="1"><nlm:affiliation>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia. Electronic address: huntington@wehi.edu.au.</nlm:affiliation>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052</wicri:regionArea>
<wicri:noRegion>VIC 3052</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Immunity</title>
<idno type="eISSN">1097-4180</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Cell Differentiation (immunology)</term>
<term>Cell Lineage (immunology)</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Inhibitor of Differentiation Protein 2 (immunology)</term>
<term>Interleukin-15 (immunology)</term>
<term>Killer Cells, Natural (cytology)</term>
<term>Killer Cells, Natural (immunology)</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Mutant Strains</term>
<term>Receptors, Interleukin-15 (immunology)</term>
<term>Receptors, Interleukin-15 (metabolism)</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
<term>Transcription Factors (immunology)</term>
<term>Transcription Factors (metabolism)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cellules tueuses naturelles (cytologie)</term>
<term>Cellules tueuses naturelles (immunologie)</term>
<term>Cytométrie en flux</term>
<term>Différenciation cellulaire (immunologie)</term>
<term>Facteurs de transcription (immunologie)</term>
<term>Facteurs de transcription (métabolisme)</term>
<term>Femelle</term>
<term>Interleukine-15 (immunologie)</term>
<term>Lignage cellulaire (immunologie)</term>
<term>Mâle</term>
<term>Protéine d'inhibition de la différenciation-2 (immunologie)</term>
<term>RT-PCR</term>
<term>Récepteurs à l'interleukine-15 (immunologie)</term>
<term>Récepteurs à l'interleukine-15 (métabolisme)</term>
<term>Souches mutantes de souris</term>
<term>Souris</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Inhibitor of Differentiation Protein 2</term>
<term>Interleukin-15</term>
<term>Receptors, Interleukin-15</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules tueuses naturelles</term>
</keywords>
<keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Killer Cells, Natural</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules tueuses naturelles</term>
<term>Différenciation cellulaire</term>
<term>Facteurs de transcription</term>
<term>Interleukine-15</term>
<term>Lignage cellulaire</term>
<term>Protéine d'inhibition de la différenciation-2</term>
<term>Récepteurs à l'interleukine-15</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Cell Differentiation</term>
<term>Cell Lineage</term>
<term>Killer Cells, Natural</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Receptors, Interleukin-15</term>
<term>Transcription Factors</term>
</keywords>
<keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription</term>
<term>Récepteurs à l'interleukine-15</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Cells, Cultured</term>
<term>Female</term>
<term>Flow Cytometry</term>
<term>Male</term>
<term>Mice</term>
<term>Mice, Mutant Strains</term>
<term>Reverse Transcriptase Polymerase Chain Reaction</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Cytométrie en flux</term>
<term>Femelle</term>
<term>Mâle</term>
<term>RT-PCR</term>
<term>Souches mutantes de souris</term>
<term>Souris</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">The inhibitor of DNA binding 2 (Id2) is essential for natural killer (NK) cell development with its canonical role being to antagonize E-protein function and alternate lineage fate. Here we have identified a key role for Id2 in regulating interleukin-15 (IL-15) receptor signaling and homeostasis of NK cells by repressing multiple E-protein target genes including Socs3. Id2 deletion in mature NK cells was incompatible with their homeostasis due to impaired IL-15 receptor signaling and metabolic function and this could be rescued by strong IL-15 receptor stimulation or genetic ablation of Socs3. During NK cell maturation, we observed an inverse correlation between E-protein target genes and Id2. These results shift the current paradigm on the role of ID2, indicating that it is required not only to antagonize E-proteins during NK cell commitment, but constantly required to titrate E-protein activity to regulate NK cell fitness and responsiveness to IL-15.</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Autriche</li>
<li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
<li>Victoria (État)</li>
<li>Vienne (Autriche)</li>
</region>
<settlement><li>Marseille</li>
<li>Melbourne</li>
<li>Vienne (Autriche)</li>
</settlement>
<orgName><li>Université de Melbourne</li>
</orgName>
</list>
<tree><country name="Australie"><region name="Victoria (État)"><name sortKey="Delconte, Rebecca B" sort="Delconte, Rebecca B" uniqKey="Delconte R" first="Rebecca B" last="Delconte">Rebecca B. Delconte</name>
</region>
<name sortKey="Alexander, Warren S" sort="Alexander, Warren S" uniqKey="Alexander W" first="Warren S" last="Alexander">Warren S. Alexander</name>
<name sortKey="Belz, Gabrielle T" sort="Belz, Gabrielle T" uniqKey="Belz G" first="Gabrielle T" last="Belz">Gabrielle T. Belz</name>
<name sortKey="Carotta, Sebastian" sort="Carotta, Sebastian" uniqKey="Carotta S" first="Sebastian" last="Carotta">Sebastian Carotta</name>
<name sortKey="Corcoran, Lynn M" sort="Corcoran, Lynn M" uniqKey="Corcoran L" first="Lynn M" last="Corcoran">Lynn M. Corcoran</name>
<name sortKey="Huntington, Nicholas D" sort="Huntington, Nicholas D" uniqKey="Huntington N" first="Nicholas D" last="Huntington">Nicholas D. Huntington</name>
<name sortKey="Hutchinson, Dana S" sort="Hutchinson, Dana S" uniqKey="Hutchinson D" first="Dana S" last="Hutchinson">Dana S. Hutchinson</name>
<name sortKey="Kolesnik, Tatiana B" sort="Kolesnik, Tatiana B" uniqKey="Kolesnik T" first="Tatiana B" last="Kolesnik">Tatiana B. Kolesnik</name>
<name sortKey="Mielke, Lisa A" sort="Mielke, Lisa A" uniqKey="Mielke L" first="Lisa A" last="Mielke">Lisa A. Mielke</name>
<name sortKey="Nicholson, Sandra E" sort="Nicholson, Sandra E" uniqKey="Nicholson S" first="Sandra E" last="Nicholson">Sandra E. Nicholson</name>
<name sortKey="Nutt, Stephen L" sort="Nutt, Stephen L" uniqKey="Nutt S" first="Stephen L" last="Nutt">Stephen L. Nutt</name>
<name sortKey="Rankin, Lucille C" sort="Rankin, Lucille C" uniqKey="Rankin L" first="Lucille C" last="Rankin">Lucille C. Rankin</name>
<name sortKey="Sathe, Priyanka" sort="Sathe, Priyanka" uniqKey="Sathe P" first="Priyanka" last="Sathe">Priyanka Sathe</name>
<name sortKey="Seillet, Cyril" sort="Seillet, Cyril" uniqKey="Seillet C" first="Cyril" last="Seillet">Cyril Seillet</name>
<name sortKey="Shi, Wei" sort="Shi, Wei" uniqKey="Shi W" first="Wei" last="Shi">Wei Shi</name>
<name sortKey="Smyth, Mark J" sort="Smyth, Mark J" uniqKey="Smyth M" first="Mark J" last="Smyth">Mark J. Smyth</name>
<name sortKey="Ushiki, Takashi" sort="Ushiki, Takashi" uniqKey="Ushiki T" first="Takashi" last="Ushiki">Takashi Ushiki</name>
<name sortKey="Zhang, Jian Guo" sort="Zhang, Jian Guo" uniqKey="Zhang J" first="Jian-Guo" last="Zhang">Jian-Guo Zhang</name>
</country>
<country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Minnich, Martina" sort="Minnich, Martina" uniqKey="Minnich M" first="Martina" last="Minnich">Martina Minnich</name>
</region>
<name sortKey="Busslinger, Meinrad" sort="Busslinger, Meinrad" uniqKey="Busslinger M" first="Meinrad" last="Busslinger">Meinrad Busslinger</name>
</country>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Vivier, Eric" sort="Vivier, Eric" uniqKey="Vivier E" first="Eric" last="Vivier">Eric Vivier</name>
</region>
</country>
</tree>
</affiliations>
</record>
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